Friday, May 1, 2009

Part 2 HIV Multiple choice questions

6q: what is the name of the species of the chimpanzee that has been established as the natural reservoir of HIV-1 ?

7q: HIV-2 is more closely related phylogenetically to which virus ?

a. HIV-1 of chimpanzees
b. Simian immunodeficiency virus ( SIV ) in sooty mangabeys
c. SIV in sykes
d. SIV in African green monkeys

8q: what are the two major envelope proteins that surround the HIV virion ?

a. gp 120 and gp 40
b. gp 120 and gp 41
c. gp 120 and gp 42
d. gp 120 and gp 43

9q: all of the following are true about HIV except ?

a. it is a DNA virus
b. it has the enzyme reverse transcriptase
c. the gp120 protein binds to the host cell via the receptor called CD4 molecule
d. the CD4 molecule is a protein found predominantly on a subset of T lymphocytes
e. the CD4 is also present on monocytes/macrophages and dendritic/langerhans cells

10q: once gp120 binds to CD4 , the gp120 undergoes a conformational change that facilitates binding to one of a group of co-receptors . what are the two major co-receptors to which HIV attaches ?

a. CCR5 and CXCR4
b. CCR6 and CXCR5
c. CCR7 and CXCR6
d. CCR8 and CXCR7

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