Part 2 HIV Multiple choice questions

6q: what is the name of the species of the chimpanzee that has been established as the natural reservoir of HIV-1 ?

answer pan troglodytes troglodytes

7q: HIV-2 is more closely related phylogenetically to which virus ?


a. HIV-1 of chimpanzees
b. Simian immunodeficiency virus ( SIV ) in sooty mangabeys
c. SIV in sykes
d. SIV in African green monkeys

answer b . SIV in sooty mangabeys

8q: what are the two major envelope proteins that surround the HIV virion ?


a. gp 120 and gp 40
b. gp 120 and gp 41
c. gp 120 and gp 42
d. gp 120 and gp 43

answer b . gp 120 and gp 41 . gp 120 externally and gp 41 below it .

9q: all of the following are true about HIV except ?


a. it is a DNA virus
b. it has the enzyme reverse transcriptase
c. the gp120 protein binds to the host cell via the receptor called CD4 molecule
d. the CD4 molecule is a protein found predominantly on a subset of T lymphocytes
e. the CD4 is also present on monocytes/macrophages and dendritic/langerhans cells

answer a . HIV is a RNA virus and not a DNA virus

10q: once gp120 binds to CD4 , the gp120 undergoes a conformational change that facilitates binding to one of a group of co-receptors . what are the two major co-receptors to which HIV attaches ?


a. CCR5 and CXCR4
b. CCR6 and CXCR5
c. CCR7 and CXCR6
d. CCR8 and CXCR7

answer a . CCR5 and CXCR4