Causes of Bone marrow suppression in HIV infection

General causes :


1. HIV infection itself
2. Mycobacterial infections
3. Fungal infections
4. B19 Parvovirus infection
5. Lymphoma 


Drugs used in HIV patient which cause Bone marrow suppression :


1. Zidovudine
2. Dapsone
3. trimethoprim/sulfamethoxazole
4. Pyrimethamine
5. 5-Flucytosine
6. Ganciclovir
7. Interferon-alpha
8. Trimetrexate
9. Foscarnet 

Part 14 HIV Multiple choice questions

66q: what is most common manifestation of pulmonary disease in HIV infected patients ?


a. pneumonia
b. carcinoma
c. bronchiectasis
d. asthma

answer a . pneumonia, mostly caused by pneumococcus and H.influenza and P. Jiroveci

67q: what is the treatment of choice for severe pneumocystis carinii disease in a patient unable to tolerate TMP/SMX ?


a. intravenous pentamidine
b. intravenous dapsone
c. intravenous clindamycin
d. intravenous primaquine

answer a, intravenous pentamidine

68q: what is the most common presentation of syphilis in HIV-infected patient ?


a. lues maligna
b. condyloma lata
c. neurosyphilis
d. none

answer b . condyloma lata

69q: all of the following are causes of bone marrow suppression in patients with HIV infection except ?


a. HIV infection itself
b. Mycobacterial infections
c. Fungal infections
d. B19 parvovirus infections
e. Lymphoma
f. All the above

answer f . all the above

70q: all of the following medications used in an HIV patient cause bone marrow suppression except ?


a. zidovudine
b. tenofovir
c. ganciclovir
d. interferon-alpha
e. foscarnet

answer b . tenofovir has the potential for renal toxicity but does not cause bone marrow suppression